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SyntheX uses the power of genetics and synthetic biology to build the next generation of drug discovery engines. 

We discover and develop therapeutics for conventionally undruggable targets using functional selection to target currently inaccessible mechanisms of action.

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OUR TECHNOLOGY

We have developed ToRPPIDO to discover disruptors of protein-protein interactions, and ToRNeDO to discover molecular glue-based functional protein degraders using a pre-specified E3 ligase and a neosubstrate of interest.

Our platforms can use canonical small molecule HTS approaches or select from our proprietary genetically encoded peptide and rigidified scaffold libraries of billions of compounds.

Technology

OUR PIPELINE

Our internal programs are focused on oncology. We select genetically validated targets based on the concepts of oncogene addiction and synthetic lethality.

The goal of our approach is to minimize clinical resistance pathways by modulating established targets in orthogonal ways.
 

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Pipeline
Team

THE LEADERSHIP TEAM

Co-Founder & CEO

Co-Founder & CSO

Head of Finance & Operations

SCIENTIFIC ADVISORY BOARD

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Andrew Perlman, MD, PhD

News

Featured News

SyntheX and Bristol Myers Squibb Enter Into a Research Collaboration to Discover and Develop Targeted Protein Degradation (TPD) Therapeutics

Investors

OUR INVESTORS

SOSV
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8VC

INCUBATOR & ACCELERATOR SUPPORT

IndieBio
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JLabs
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Careers
Lab Experiment

OPEN POSITIONS

Imagine. Design. Build. Create.

Are you an enthusiastic scientist who's excited about using synthetic biology to advance drug discovery?

We are always keeping an eye out for talented members to join our growing team.

RESEARCH ASSISTANTS (BS or MS):

  • Molecular Biology

  • Biochemistry

  • Cell Biology

  • Peptide Chemistry

RESEARCH SCIENTISTS (PhD+):

  • Proteomics

  • Enzyme Engineering

  • Microbial Genetics

  • Biochemistry

  • Cancer Cell Biology

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Contact

GET IN TOUCH

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