9d71ae2c9dfe57e6151506fbedd7b7d2.jpg

SyntheX is using the power of genetics and synthetic biology to build the next generation of drug discovery engines. 

We create cell-based platforms to produce and functionally select molecules to target conventionally 'undruggable' proteins.

OUR TECHNOLOGY

Using genetically engineered circuits, our platform technologies rely on functional intracellular drug selection as opposed to in vitro screening. This allows us to discover compounds with novel modes of action that can modulate protein interactions in either orthosteric or allosteric ways.

 

We have developed ToRPPIDO to discover disruptors of protein-protein interactions, and ToRNeDO to discover functional protein degraders using a specific E3 ligase and a neosubstrate of interest.

Our platforms can use canonical small molecule HTS approaches or our proprietary DNA encoded peptide and macrocycle libraries.

 

OUR PIPELINE

Our internal programs are focused on oncology. We select targets based on oncogene addiction and synthetic lethality.

 

Pipetting Samples
 
 

THE FOUNDING TEAM

Maria%20Soloveychik%20SyntheX%20square_e
Charly Chahwan

Maria Soloveychik

Co-Founder & Chief Executive Officer

  • Grey LinkedIn Icon

Charly Chahwan

Co-Founder & Chief Science Officer

  • Grey LinkedIn Icon

ADVISORY BOARD

Arvind Gupta
Andrew Perlman

Arvind Gupta

Director

  • Grey LinkedIn Icon

Andrew Perlman, MD, PhD

SAB 

  • Grey LinkedIn Icon

Leonard Post, PhD

SAB 

  • Grey LinkedIn Icon

OUR INVESTORS

oriza logo 3.png
SOSV
8VC
 

INCUBATOR AND ACCELERATOR SUPPORT

 
Lab Experiment

OPEN POSITIONS

Imagine. Design. Build. Create.

Are you an enthusiastic scientist who wants to bring therapies into the clinic? Do you want to use synthetic biology to advance drug discovery? We are always keeping an eye out for new talented members to join the team.

RESEARCH ASSISTANT WITH MOLECULAR BIOLOGY EXPERTISE (BSC, OR MSC)

RESEARCH ASSISTANT WITH BIOCHEMISTRY EXPERTISE (BSC, OR MSC)

EXPERIENCED PROTEOMIC SCIENTIST (PHD+)

EXPERIENCED IMMUNOLOGIST (PHD+)

zoomed in2 on white.png
 

GET IN TOUCH

  • Twitter
  • LinkedIn Social Icon

© 2020 by SyntheX

409 Illinois st, San Francisco, CA 94158