9d71ae2c9dfe57e6151506fbedd7b7d2.jpg

SyntheX is using the power of genetics and synthetic biology to build the next generation of drug discovery engines. 

We discover and develop therapeutics for conventionally undruggable targets using functional selection to target currently inaccessible mechanisms of action.

OUR TECHNOLOGY

Using genetically engineered circuits, our platform technologies rely on functional intracellular drug selection as opposed to in vitro screening. This allows us to discover compounds with novel modes of action that can modulate protein interactions in orthosteric or allosteric ways.
 
We have developed ToRPPIDO to discover disruptors of protein-protein interactions, and ToRNeDO to discover molecular glue-based functional protein degraders using a pre-specified E3 ligase and a neosubstrate of interest.

Our platforms can use canonical small molecule HTS approaches or select from our proprietary genetically encoded peptide and rigidified scaffold libraries of billions of compounds.

 

OUR PIPELINE

Our internal programs are focused on oncology. We select drug targets based on oncogene addiction and synthetic lethality and target them in orthogonal ways.
 

220301 pipeline.png
Pipetting Samples
 
 

THE FOUNDING TEAM

Maria%20Soloveychik%20SyntheX%20square_e
Charly Chahwan

Maria Soloveychik

Co-Founder & Chief Executive Officer

  • Grey LinkedIn Icon

Charly Chahwan

Co-Founder & Chief Science Officer

  • Grey LinkedIn Icon

ADVISORY BOARD

robert williamson_edited.jpg
Leonard Post
Andrew Perlman

Robert Williamson

Senior Advisor

  • Grey LinkedIn Icon

Leonard Post, PhD

SAB 

  • Grey LinkedIn Icon

Andrew Perlman, MD, PhD

SAB 

  • Grey LinkedIn Icon

Tomi Sawyer, PhD

SAB 

  • Grey LinkedIn Icon

OUR INVESTORS

SOSV
omx logo.jfif
oriza%20ventures%20logo_edited.jpg
8VC
 

INCUBATOR AND ACCELERATOR SUPPORT

IndieBio
clsi fast logo.png
JLabs
MBC biolabs logo.png
 
Lab Experiment

OPEN POSITIONS

Imagine. Design. Build. Create.

Are you an enthusiastic scientist who wants to bring therapies into the clinic? Do you want to use synthetic biology to advance drug discovery? We are always keeping an eye out for new talented members to join our growing team.

RESEARCH ASSISTANTS (BS or MS):

  • Molecular Biology

  • Biochemistry

  • Cell Biology

  • Peptide Chemistry

RESEARCH SCIENTISTS (PhD+):

  • Proteomics

  • Enzyme Engineering

  • Microbial Genetics

  • Biochemistry

  • Cancer Cell Biology

zoomed in2 on white.png
 

GET IN TOUCH

Thanks! Message sent.

Join our mailing list

Join our mailing list