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SyntheX is using the power of genetics and synthetic biology to build the next generation of drug discovery engines. 

We create cell-based platforms to produce and functionally select molecules to target conventionally 'undruggable' proteins.

OUR TECHNOLOGY

Using genetically engineered circuits, our platform technologies rely on functional intracellular drug selection as opposed to in vitro screening. This allows us to discover compounds with novel modes of action that can modulate protein interactions in either orthosteric or allosteric ways.
 
We have developed ToRPPIDO to discover disruptors of protein-protein interactions, and ToRNeDO to discover molecular glue-based functional protein degraders using a pre-specified E3 ligase and a neosubstrate of interest.

Our platforms can use canonical small molecule HTS approaches or select from our proprietary genetically encoded peptide and rigidified scaffold libraries of billions of compounds.

 

OUR PIPELINE

Our internal programs are focused on oncology. We select targets based on oncogene addiction and synthetic lethality.

 

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Pipetting Samples
 
 

THE FOUNDING TEAM

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Charly Chahwan

Maria Soloveychik

Co-Founder & Chief Executive Officer

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Charly Chahwan

Co-Founder & Chief Science Officer

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ADVISORY BOARD

Arvind Gupta
Andrew Perlman

Arvind Gupta

Director

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Andrew Perlman, MD, PhD

SAB 

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Leonard Post, PhD

SAB 

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OUR INVESTORS

SOSV
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8VC
 

INCUBATOR AND ACCELERATOR SUPPORT

IndieBio
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JLabs
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Lab Experiment

OPEN POSITIONS

Imagine. Design. Build. Create.

Are you an enthusiastic scientist who wants to bring therapies into the clinic? Do you want to use synthetic biology to advance drug discovery? We are always keeping an eye out for new talented members to join the team.

RESEARCH ASSISTANT WITH CELL BIOLOGY EXPERTISE (BSC, OR MSC)

RESEARCH ASSISTANT WITH BIOCHEMISTRY EXPERTISE (BSC, OR MSC)

EXPERIENCED PROTEOMIC SCIENTIST (PHD+)

EXPERIENCED MICROBIAL GENETICIST (PHD+)

EXPERIENCED BIOCHEMIST (PHD+)

EXPERIENCED CELL BIOLOGIST (PHD+)

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GET IN TOUCH

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