Targeting the Undruggable
SyntheX is using the power of genetics and synthetic biology to build the next generation of drug discovery engines.
We discover and develop therapeutics for conventionally undruggable targets using functional selection to target currently inaccessible mechanisms of action.
We have developed ToRPPIDO to discover disruptors of protein-protein interactions, and ToRNeDO to discover molecular glue-based functional protein degraders using a pre-specified E3 ligase and a neosubstrate of interest.
Our platforms can use canonical small molecule HTS approaches or select from our proprietary genetically encoded peptide and rigidified scaffold libraries of billions of compounds.
Our internal programs are focused on oncology. We select drug targets based on oncogene addiction and synthetic lethality and target them in orthogonal ways.
Tomi Sawyer, PhD
Imagine. Design. Build. Create.
Are you an enthusiastic scientist who's excited about using synthetic biology to advance drug discovery?
We are always keeping an eye out for talented members to join our growing team.
RESEARCH ASSISTANTS (BS or MS):
RESEARCH SCIENTISTS (PhD+):
Cancer Cell Biology