SyntheX is using the power of genetics and synthetic biology to build the next generation of drug discovery engines. 

We discover and develop therapeutics for conventionally undruggable targets using functional selection to target currently inaccessible mechanisms of action.

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OUR TECHNOLOGY

We have developed ToRPPIDO to discover disruptors of protein-protein interactions, and ToRNeDO to discover molecular glue-based functional protein degraders using a pre-specified E3 ligase and a neosubstrate of interest.

Our platforms can use canonical small molecule HTS approaches or select from our proprietary genetically encoded peptide and rigidified scaffold libraries of billions of compounds.

 

OUR PIPELINE

Our internal programs are focused on oncology. We select drug targets based on oncogene addiction and synthetic lethality and target them in orthogonal ways.
 

Synthex Pipeline
 
 

THE FOUNDING TEAM

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Charly Chahwan

Maria Soloveychik

Co-Founder & Chief Executive Officer

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Charly Chahwan

Co-Founder & Chief Science Officer

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ADVISORY BOARD

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Leonard Post
Andrew Perlman

Robert Williamson

Senior Advisor

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Leonard Post, PhD

SAB 

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Andrew Perlman, MD, PhD

SAB 

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SAB 

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Tomi Sawyer, PhD

 

Featured News

SyntheX and Bristol Myers Squibb Enter Into a Research Collaboration to Discover and Develop Targeted Protein Degradation (TPD) Therapeutics

 

OUR INVESTORS

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8VC

INCUBATOR & ACCELERATOR SUPPORT

IndieBio
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JLabs
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Lab Experiment

OPEN POSITIONS

Imagine. Design. Build. Create.

Are you an enthusiastic scientist who's excited about using synthetic biology to advance drug discovery?

We are always keeping an eye out for talented members to join our growing team.

RESEARCH ASSISTANTS (BS or MS):

  • Molecular Biology

  • Biochemistry

  • Cell Biology

  • Peptide Chemistry

RESEARCH SCIENTISTS (PhD+):

  • Proteomics

  • Enzyme Engineering

  • Microbial Genetics

  • Biochemistry

  • Cancer Cell Biology

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